Determination of Fenofibrate in Fenofibrate Capsules by HPLC / 中国药师
China Pharmacist
; (12): 1423-1424, 2016.
Article
de Zh
| WPRIM
| ID: wpr-495151
Bibliothèque responsable:
WPRO
ABSTRACT
Objective:To establish a method for the determination of fenofibrate in fenofibrate capsules .Methods: HPLC was performed on a Dikma Diamonsil C18column (150 mm ×4.6 mm, 5 μm).The mobile phase was acetonitrile-water (7030, adjusting pH to 2.5 with phosphoric acid) and the detection wavelength was 286 nm.The flow rate was 1.0 ml· min-1 and the column tempera-ture was 30 ℃.The injection volume was 20 μl.Results:The linear range of fenofibrate was 10.07-60.42 μg· ml-1(r=0.9996) and the average recovery was 99.26%(RSD=0.5%,n=6).Conclusion:The method is simple, accurate and special, which can be used for the quality control of fenofibrate capsules .
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WPRIM
langue:
Zh
Texte intégral:
China Pharmacist
Année:
2016
Type:
Article