Two Cases of Trisomy 19 as a Sole Chromosomal Abnormality in Myeloid Disorders / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 174-178, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-49542
ABSTRACT
Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality however, trisomy 19 rarely occurs as a sole chromosomal abnormality and, to date, it has only been reported in 48 hematopoietic malignancies, 1 case of adenocarcinoma and 1 case of astrocytic tumor. Here, we report two additional cases of trisomy 19 as a sole karyotypic aberration in myeloid malignancies. One of these cases involved a 6-month-old male who was diagnosed with acute myeloid leukemia minimally differentiated. His karyotype was 47,XY,+19[20]. He expired 5 days after diagnosis. Another case occurred in an 80-yr-old female who had refractory anemia with excess blasts. Her karyotype was 47,XX,+19[16]/46,XX[4]. Four months later, her peripheral blood smears suggested that the disease had progressed, but she refused further evaluation. Based on a review of the existing literature and the results of this report, trisomy 19 not only as a secondary abnormality but also as a sole karyotypic aberration is strongly associated with myeloid disorder; however, it is not preferentially found in specific FAB subgroups of myelodysplasic syndrome or acute myeloid leukemia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Trisomie
/
Chromosomes humains de la paire 19
/
Anémie réfractaire
/
Leucémie myéloïde
/
Maladie aigüe
/
Caryotypage
Limites du sujet:
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Anglais
Texte intégral:
The Korean Journal of Laboratory Medicine
Année:
2008
Type:
Article
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