Research progress of transcription factor sal-like protein 4 / 肿瘤研究与临床

ABSTRACT

Sal-like protein 4 (SALL4), a newly discovered oncogenes, plays an important role in the formation of embryo, maintenance of embryonic stem cell pluripotency and self-renewal. SALL4 not only has a close relationship with hereditary disease, benign disease, malignant tumor, blood system tumor and germ cell tumors, but also chemoresistance and poor prognosis. SALL4 obtains biological functions by adjusting different signaling pathways, transcription factors and epigenetic modulation. Further mechanism study of SALL4 and its relationship with various diseases will provide new opportunities for the treatment of diseases.