Effect of Danhong injection on serum levels of cystatin C, homocysteine and inflammatory factors in elderly patients with chronic heart failure / 中国生化药物杂志

ABSTRACT

Objective To analyse the effect of Danhong injection on serum levels of cystatin C (CysC), homocysteine (Hcy) and inflammatory factors in elderly patients with chronic heart failure.Methods Fifty-two elderly patients who were diagnosed with chronic heart failure in our hospital were collected.All patients were randomly divided into experimental group and control group, 26 cases in each group, the control group were given conventional therapy, the experimental group received Danhong injection adjunctive therapy on the basis of the control group.After treatment, the serum levels of CysC, Hcy, nuclear transcription factorκB (NF-κB), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), heart function and incidence of adverse reactions were detected in all patients.Results After treatment, compared with control group, the serum levels of CysC and Hcy were lower, the serum levels of NF-κB,IL-1βand TNF-αwere lower in the experimental group, and the levels of left ventricular ejection fraction ( LVEF) and stroke volume (SV) were lower in the experimental group, there were significant difference between two groups (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The Danhong injection therapy could significantly reduce the serum levels of CysC, Hcy and inflammatory factors in elderly patients with chronic heart failure,reduce the inflammatory reaction, improve the heart function, and have high safety.