Protect role of Netrin-1 in inflammatory response / 中华危重病急救医学
Chinese Critical Care Medicine
; (12): 756-760, 2016.
Article
de Zh
| WPRIM
| ID: wpr-497310
Bibliothèque responsable:
WPRO
ABSTRACT
Neuronal guidance factor Netrin-1 has been known to be involved in nervous system development by controlling neuronal migration through both chemoattractive and chemo-repulsive signaling by binding different receptors. Netrin-1 has been shown to play a positively regulatory role during inflammatory process recently. Since the chemorepulsive receptors were found in leukocytes, it is suggest that Netrin-1 played a protective role in tissue through inhibiting leukocyte trafficking and accumulating during inflammatory process in researches. It is demonstrated that Netrin-1 can limit inflammatory response through the involvement of inflammatory cascades, attenuate hypoxia-inducible tissue injury and suppress apoptosis concurrently. It is indicated that Netrin-1 can be a novel target in future through preventing and inhibiting inflammatory diseases in these researches. This review will focus on recent relevant advances and in-depth study to elucidate its mechanism of anti-inflammation.
Texte intégral:
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Critical Care Medicine
Année:
2016
Type:
Article