Analysis on distribution and drug resistance of pathogenic bacteria causing postoperative infections in gastrointestinal surgical inpatients / 国际检验医学杂志

ABSTRACT

Objective To explore the distribution and drug resistance of pathogenic bacteria causing postoperative infections in gastrointestinal surgical inpatients during 2011-2015 in order provide the basis for clinical rational use of antibacterial drugs .Meth‐ods The bacterial species identification and drug susceptibility test were performed by adopting the BacT/ALERT3D automatic culture system and VITEK‐2 system .The analysis was performed by using the WHONET5 .6 statistical software .Results Among 1 140 specimens ,753 strains of pathogenic bacteria were detected .The specimens sources were mainly blood ,sputum ,abdominal drainage fluid ,pus and urine (77 .7% ) .In pathogenic bacteria ,537 strains (71 .3% ) were Gram‐negative bacteria(G-) ,198 strains (26 .3% ) were Gram positive bacteria(G+ ) and 18 strains (2 .4% ) were fungi .The top five detected pathogenic bacteria were E . coli (32 .3% ) ,klebsiella pneumoniae (11 .4% ) ,pseudomonas aeruginosa (10 .0% ) ,staphylococcus aureus (8 .1% ) and acinetobact‐er baumannii (5 .8% ) .E .coli ,klebsiella pneumoniae and pseudomonas aeruginosa had higher resistance to second and third genera‐tion cephalosporin antibacterials ,but had lower resistance to piperacillin/tazobactam and imipenen ,acinetobacter baumannii had higher resistance to multiple antimicrobial agents (> 50% ) ,no vancomycin‐resistant positive staphylococcus strain was found;Gram‐positive staphylococcus aureus had higher resistance to quinolones (>40% ) and traditional antibiotics of penicillin and eryth‐romycin(>50% );enterococcus faecalis and enterococcus faecium were highly sensitive to vancomycin and linezolid .Conclusion Strengthening the bacterial drug resistance surveillance and reducing the generation and spread of drug‐resistant bacteria is of great significance to improve the effect of gastrointestinal surgical infection treatment .