Role of autophagy in development and progression of acute pancreatitis / 临床肝胆病杂志

ABSTRACT

Acute pancreatitis is considered an autodigestive disorder in which inappropriate activation of trypsinogen to trypsin within pancre-atic acinar cells leads to the development of pancreatitis.Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents,and it is one of the early pathological processes in acute pancreatitis.Autophagic flux is impaired in acute pancreatitis,which mediates the key pathologic responses of this disease.Impaired autophagy,dysfunction of lysosomes,and dysregulation of autophagy suggest a disorder of the endolysosomal pathway in acute pancreatitis.The role of autophagy in acute pancreatitis is discussed from the aspects of au-tophagic process,autophagy and activation of trypsinogen,impaired autophagy and acute pancreatitis,and defective autophagy promoting in-flammation.