Effect of transcatheter arterial chemoembolization combined with interferon adjuvant therapy in treatment of ad-vanced primary liver cancer:a meta-analysis / 临床肝胆病杂志

ABSTRACT

Objective Toinvestigatetheeffectoftranscatheterarterialchemoembolization(TACE)combinedwithinterferon(IFN)adju-vanttherapyinthetreatmentofadvancedprimarylivercancer,andtoprovidenewideasforadjuvanttherapiesafterTACE.Methods The databases including Cochrane Library,PubMed,Medline,Embase,CNKI,Wanfang Data,and VIP were searched to obtain all articles pub-lished before January 2015,and the randomized controlled trials (RCTs)about the comparison between TACE combined with IFN and TACE alone published in journals at home and abroad were included.Quality assessment and data extraction were performed for these articles,and Revman5.1softwarewasappliedforthemeta-analysis.Results Atotalof6RCTswereincluded,consistingof311patientsintheIFN adjuvant therapy group and 308 patients in the placebo group.The results of the meta -analysis showed that compared with the placebo group,the IFN adjuvant treatment group had significantly lower 1 -,2-,and 3-year recurrence rates and a significantly higher 1 -year survivalrate(P=0.006,0.002,0.002,and0.030).Conclusion IFNadjuvanttherapycanreducetheriskoflivercancerrecurrence after TACE and improve the patients′survival rate.