The research progression on the relationship between TRPS1 and tumors / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 78-81, 2015.
Article
de Zh
| WPRIM
| ID: wpr-499249
Bibliothèque responsable:
WPRO
ABSTRACT
Tricho-rhinophalangeal syndrome -1 gene(TRPS1),a new GATA family member,is highly prevalent in many tissues .It plays an important role in the regulation of cell proliferation and tissue development . The genetic missing of TRPS1 may lead to Tricho-rhinophalangeal syndrome .In recent years,studies have dem-onstrated that TRPS1 abnormal expression exists in a variety of tumors , and is associated with carcinogenesis , lymph node metastasis,pathological grading and clinical staging .Therefore,TRPS1 is considered as a potential tumor suppressor gene ,its overexpression may be one of mechanisms for carcinogenesis and progression of cancer . This review focuses on the role of TRPS 1 gene in carcinogenesis and progression of carcinoma ,and further to pro-vide a new biomarker for predicting cancer prognosis and therapy .
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Practical Oncology Journal
Année:
2015
Type:
Article