Effect of Telmisartan Combined with Benazepril on Plasma Brain Natriuretic Peptide of Patients Underwent Permanent Cardiac Pacemaker Implantation / 中国药房

ABSTRACT

OBJECTIVE:To exlpore the effect of telmisartan combine with benazepril on plasma brain natriuretic peptide (BNP) of patients underwent permanent cardiac pacemaker implantation. METHODS:96 patients underwent permanent cardiac pacemaker implantation were randomly divided into group A,B and C with 32 cases in each group. Based on routine treatment, group A was given telmisartan 80 mg/d immediately after operation,qd,group B given benazepril 10 mg/d,qd,group C given telmisartan 40 mg/d+ benazepril 10 mg/d,qd. All of them was given medicine for 6 months. LEVF,CI,Ren,BNP,AngⅡ and Ald were compared among 3 groups. RESULTS:After 6 months,BNP levels of 3 groups were higher than before,with statistical significance (P0.05);those of group A and B were decreased,with statistical significance(P<0.05);those of group C were higher than those of group A and B, with statistical significance(P<0.05). The levels of Ren,AngⅡ and Ald in 3 groups were decreased after treatment,with statisti-cal significance (P<0.05);those of group C were lower than those of group A and B,with statistical significance (P<0.05). CONCLUSIONS:Telmisartan combined with benazepril can improve ventricular remodeling and heart function,and reduce plasma BNP levels in patients underwent permanent cardiac pacemaker implantation.