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Plasma D-dimer Can Effectively Predict the Prospective Occurrence of Ascites in Advanced Schistosomiasis Japonica Patients
The Korean Journal of Parasitology ; : 167-174, 2017.
Article Dans Anglais | WPRIM | ID: wpr-50086
ABSTRACT
China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients' ascites were confined in the kidney area with median area of 20 mm². The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer (0.71±2.44 μg/L vs 0.48±2.12 μg/L, P=0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs 44.50 μg/L). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI 0.54–0.73) and the cutoff value as 0.81 μg/L. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI 0.68–0.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Examen physique / Plasma sanguin / Ascites / Schistosoma japonicum / Schistosomiase / Schistosomiase artérioveineuse / Fibrine / Études cas-témoins / Chine / Études prospectives Type d'étude: Etude diagnostique / Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains Pays comme sujet: Asie langue: Anglais Texte intégral: The Korean Journal of Parasitology Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Examen physique / Plasma sanguin / Ascites / Schistosoma japonicum / Schistosomiase / Schistosomiase artérioveineuse / Fibrine / Études cas-témoins / Chine / Études prospectives Type d'étude: Etude diagnostique / Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains Pays comme sujet: Asie langue: Anglais Texte intégral: The Korean Journal of Parasitology Année: 2017 Type: Article