Clinical Observation of Doxofylline and Aminophylline in the Treatment of Children with Capillary Bronchitis / 中国药房

ABSTRACT

OBJECTIVE:To compared the efficacy and safety of doxofylline and aminophylline in the treatment of children with capillary bronchitis. METHODS:Totally 120 children with capillary bronchitis were randomly divided into observation group and control group. All children were given routine treatment,including oxygen inhalation,sputum suction and infusion supporting. Based on it,the observation group was treated by doxofylline 4 mg/kg adding into 15% glucose injection 50 ml by infusion,qd;control group was treated by aminophylline 4 mg/kg adding into 15% glucose injection 50 ml by infusion,bid. The course was 7 d. The capillary bronchitis severity scores,remission time of clinical symptoms,hospitalization time,utilization rate of glucocorticoid and the incidence of adverse reactions were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,with significant difference(P<0.05). After 48 h and 72 h,the capillary bronchitis severity scores were significantly lower than before,and observation group was lower than control group after 72 h,with significant differences(P<0.05). The cough disappeared time and hospitalization time in observation group were significantly shorter than control group,and the utilization rate of glucocorticoid and the incidence of adverse reactions were significantly lower than control group,with signifi-cant differences(P<0.05). CONCLUSIONS:Based on the routine treatment,doxofylline has better efficacy and safety than amino-phylline in the treatment of children with capillary bronchitis.