Effect of CYP4F2 Gene Polymorphism on Warfarin Maintenance Dose in Chinese Population:a Systematic Review / 中国药房
China Pharmacy
;
(12): 3803-3805, 2015.
Article
Dans Chinois
| WPRIM
| ID: wpr-502695
ABSTRACT
OBJECTIVE:
To systematic review the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population,and to provide evidence-based reference for clinical treatment.METHODS:
Retrieved from Cochrane library,PubMed,EMBase,CJFD,VIP and Wanfang database,studies about the relationship between CYP4F2 gene polymorphism and warfarin maintenance dose in Chinese population were collected,and Meta-analysis was performed by using Rev Man 5.0 statis-tics software.RESULTS:
A total of 13 studies were included,involving 2 958 patients. The type of gene was type TT,type CT and type CC. Results of Meta-analysis showed the relationship between 3 gene polymorphism and warfarin maintenance dose was type TT>type CT>type CC,and there were significant differences among groups.CONCLUSIONS:
CYP4F2 gene polymorphism in Chinese population has significant correlation with warfarin maintenance dose. However,due to the limit of methodological quali-ty,large-scale and high quality studies are required for further validation of the conclusions.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Revues systématiques évaluées
langue:
Chinois
Texte intégral:
China Pharmacy
Année:
2015
Type:
Article
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