Advances in nano-delivery systems based on aptamer targeting to tumor / 国际药学研究杂志

ABSTRACT

Aptamers are kinds of single-strand oligonucleotides with high affinity to their targets. Compared to other commonly used target ligands,like antibodies,aptamers are small,non-immunogenic,as well as the undemanding in vitro screening. At pres?ent,the nano-delivery systems modified with aptamers for tumor targeting are often divided into three types:aptamers modifying on the surface of nanocarriers,such as liposomes,nanoparticles,and micelles,to form aptamer-targeted nanocarriers;aptamers conju?gating to molecular drugs or fluorescent agents to form aptamer-drug/fluorescent agent conjugates;and aptamers serving as drug carri?ers for further tumor targeting and drug delivery. In this paper,the advances in nano-delivery system based on aptamer targeting to tu?mor are summarized.