Mechanism of flavonoids against P-glycoprotein mediated tumor multidrug resistance:research advances / 国际药学研究杂志

ABSTRACT

Multidrug resistance(MDR)is one of the important reasons for the failure of chemotherapy in clinic,whereas the mechanism of MDR is very complicated. At present,it is considered that the efflux protein P-glycoprotein(P-gp)is one of the main factors which can lead to MDR,descreasing the successful rate of chemotherapy because chemotherapeutics with different structures and functions can be effluxed by P-gp. Flavonoids are found in many kinds of plants and have a wide range of pharmacological activi?ties. Besides,recent studies have reported that flavonoids can reverse the MDR of tumor and affect the expression and function of ef?flux transporter,especially P-gp. In this review,we elucidate the mechanisms of flavonoids reversing tumor MDR mediated by P-gp from the following aspectsinhibition of P-gp protein expression,inhibition of P-gp efflux function,and prevention of combining P-gp and its substrate,etc. The review can provide some ideas and references for the application of flavonoids in tumor therapy.