Mechanism of Nuclear Factor-κB in Skeletal Muscle Atrophy during Prevention and Treatment of Exercise in Patients with Chronic Obstructive Pulmonary Disease (review) / 中国康复理论与实践

ABSTRACT

@#Chronic obstructive pulmonary (COPD) has significant extra pulmonary effects, which could induce atrophy of peripheral skeletal muscle and respiratory muscles, and significantly influence the respiratory function and quality of life. Muscle nuclear factor (NF)-κB activation plays a key role in the skeletal muscle atrophy. This article discussed the potential mechanisms on how NF-κB signaling pathway increasing protein breakdown and reducing muscle regeneration. On this basis, we explored the role of NF-κB in skeletal muscle at-rophy in patients with COPD during exercise.