Clinical application of carbon nanoparticles suspension in outpatient thyroid microcarcinoma surgery / 医学研究生学报

ABSTRACT

Objective Recently a lot of studies have shown carbon nanoparticles can protect parathyroid, however, there is no application in outpatient thyroid operation. The article was to investigate the influence of carbon nanoparticles suspension ( CNS) in?jection on the operation and prognosis of outpatient thyroid microcarcinoma(TMC) surgery. Methods Retrospective analysis was conducted on the clinical data of 65 patients who underwent outpatient TMC surgery from January to June in 2015 in our hospital. The patients were divided into 2 groups:33 patients in trial group were injected with CNS, and the other 32 patients in control group under?went conventional surgery. Comparison was made in operation information, pathologic data, postoperative complications, postoperative hospital stay as well as C?reactive protein(CRP) and blood calcium of the first day after operation between the two groups. Results The average number of VI region lymph nodes in trial group(8.21±2.08)was significantly higher than that of control group(P=0.004). Removal of 5 parathyroid glands for mistake was detected in control group, but no removal of parathyroid gland was detected in trial group, showing significant difference (P=0.028). 3 patients in control group had numbness in skin, while none in trial group. The hospital stay of trial group was lowered significantly in comparison to that of control group([31.09±6.62] vs [35.75±7.37], P=0.009). The average C?reactive protein ( CRP ) of the first day after operation in trial group was much lower that of control group([7.17±5.20] vs [9.87±5.60] mg/L, P=0.048). The average blood calcium of the first day in trial group was much higher than that of control group ([2.07±0.17] vs [1.98±0.20] mmol/L, P=0.036). Conclusion Outpatient TMC surgery injected with carbon nanoparticles sus?pension can protect parathyroid gland function, reduce surgical stress and accelerate recovery.