Optimization of Forming Process of Luomai Granules by Response Surface Methodology / 中国药师
China Pharmacist
;
(12): 1665-1669, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-504525
ABSTRACT
Objective:
To optimize the forming process of Luomai granules.Methods:
With the qualified granule yield and the moisture absorption as the indicators, the excipients were screened, and through the study of granulation effect, the proportion of excip-ients was optimized. With the normalized value of qualified granule yield, solubility, hygroscopicity and sensory evaluation as the eval-uation indices, and excipients times, ethanol concentration and amount of citric acid as the main influencing factors with five levels for each, the forming process of Luomai granules was optimized by central combination design-response surface methodology.Results:
The option formula for Luomai granules was the followsthe excipients amount was 5-fold of the extract, 85% ethanol was used as the wet-ting agent, and citric acid content was 0. 3%.Conclusion:
Optimized by the central combination design-response surface method, Lu-omai granules has such advantages as high qualified yield, low hygroscopicity, good solubility, soft taste and appropriate dosage, sug-gesting the optimized preparation process of Luomai granules is reasonable and feasible.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
China Pharmacist
Année:
2016
Type:
Article
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