Outcome of radioiodine therapy in patients with papillary thyroid carcinoma concurrent with Hashimoto's thyroiditis / 中华核医学与分子影像杂志
Chinese Journal of Nuclear Medicine and Molecular Imaging
; (6): 481-485, 2016.
Article
de Zh
| WPRIM
| ID: wpr-505221
Bibliothèque responsable:
WPRO
ABSTRACT
Objective To evaluate the impact of low-dose 131I therapy and high-dose 131I therapy on the clinical outcome in PTC patients coexisting with Hashimoto's thyroiditis (HT).Methods A total of 140 non-distant metastatic PTC patients (16 males,124 females,age range:16-66 years) from July 2010 to December 2014 were enrolled in this retrospective study.Patients concurrent with HT (n=84,group A) were divided into low-dose group (1 110 MBq,n=56,group A1) and high-dose group (5 550 MBq,n=28,group A2) according to 131I ablation dose.Patients without HT (n =56) were enrolled as control group (group B),and received 1 110 MBq of 131I.The thyroid remnant ablation outcome was evaluated according to 131I diagnostic whole-body scan (Dx-WBS),neck ultrasonography (US),serum Tg and TgAb level 6-8 months after 131I ablation therapy.The successful ablation rates were compared by x2 test.Kruskal-Wallis rank sum test was also used.Results There were no significant differences among the 3 groups in terms of both clinicopathological features and postoperative remnant thyroid (H:0.203-2.944,x2:0.271-0.970,all P>0.05).When negative Dx-WBS and US were deemed as successful ablation criterion,complete ablation rate was found significantly more in group B (94.6%,53/56) than that in group A1 (82.1%,46/56;x2=4.264,P<0.05),but no significant difference was found between group A2 (85.7%,24/28) and group A1 (x2 =0.318,P>0.05).When combining negative sTg (sTg<1 μg/L,TgAb<46 kU/L) with the above 2 criterions to assess remnant ablation outcome,group B also had a higher successful rate to achieve complete ablation (85.7%,48/56) compared with group A1 (75.6%,34/45),but without statistical significance (x2=2.978,P>0.05),and no difference was observed between group A2 (12/15) and group A1 (x2=1.320,P> 0.05).Conclusion Non-distant metastatic PTC patients coexisting with HT has undesirable 131I ablation outcome compared with those without HT,increasing 131I dose is unhelpful to enhance efficiency of remnant ablation for PTC patients with HT.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Observational_studies
langue:
Zh
Texte intégral:
Chinese Journal of Nuclear Medicine and Molecular Imaging
Année:
2016
Type:
Article