The Roles of CD137 Signaling in Atherosclerosis
Korean Circulation Journal
; : 753-761, 2016.
Article
de En
| WPRIM
| ID: wpr-50583
Bibliothèque responsable:
WPRO
ABSTRACT
The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Maladies cardiovasculaires
/
Négociation
/
Récepteurs aux facteurs de nécrose tumorale
/
Athérosclérose
/
Plaque d'athérosclérose
Limites du sujet:
Animals
/
Humans
langue:
En
Texte intégral:
Korean Circulation Journal
Année:
2016
Type:
Article