Mechanisms and role of complement C5a in paraquat -induced acute lung injury / 中国药理学与毒理学杂志

ABSTRACT

The lung is a major damage tissue in paraquat(PQ)-caused acute poisoned patients. Most deaths from acute PQ poisoning can be attributed to acute lung injury(ALI). Complement activa?tion product C5a causes inflammatory cells,such as neutrophils and macrophages,to accumulate into the lung and get activated. These activated inflammatory factors generate a large number of oxidants and inflammatory sequelae named cytokine storm to mediate ALI induced by PQ poison. The review focused on the role and mechanisms of complement C5a in PQ-induced ALI.