Effect of CD105, CA125 and CA724 levels by paclitaxel combined with cisplatin in patients with cervical cancer / 中国医学装备
China Medical Equipment
; (12): 105-108, 2016.
Article
Dans Zh
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| ID: wpr-508588
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective:
To investigate the value of serum CD105, CA125 and CA724 levels in the treatment of cervical cancer with paclitaxel and cisplatin.Methods:
A total of 42 patients with cervical cancer were randomly divided into observation group (n=21) and control group (n=21). The observation group was given intravenous infusion of paclitaxel 135 mg/m2, and intravenous infusion of cisplatin 60 mg/m2 after 3 hours. The control group was given only intravenous infusion of cisplatin, during the hydration and antiemetic drugs. They need 2 courses of chemotherapy, with each chemotherapy interval of 21 days. The levels of serum CD105, CA125 and CA724 before and after treatment were compared and analyzed.Results:
The levels of CD105, CA125 and CA724 in the observation group were lower than those in the control group (t=19.119,t=22.493,t=15.46;P<0.05). There was a negative correlation between CD105, CA125 and CA724 levels and clinical efficacy (rs=-0.427,rs=-0.335,rs=-0.408;P<0.05).Conclusion:
Paclitaxel combine with cisplatin in the treatment of cervical cancer has better clinical curative effect, and the mechanism is related to lower CD105, CA125 and CA724 levels.
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China Medical Equipment
Année:
2016
Type:
Article