The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder
Psychiatry Investigation
; : 616-621, 2016.
Article
de En
| WPRIM
| ID: wpr-50901
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. METHODS: The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q, 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method. RESULTS: Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD. CONCLUSION: Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Infractions sexuelles
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Troubles de stress post-traumatique
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Superoxide dismutase
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Altération de l'ADN
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ADN
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Test ELISA
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Hydrocortisone
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Ubiquinones
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Stress oxydatif
/
Diagnostic
Type d'étude:
Diagnostic_studies
/
Qualitative_research
Limites du sujet:
Adolescent
/
Child
/
Humans
langue:
En
Texte intégral:
Psychiatry Investigation
Année:
2016
Type:
Article