The prediction value of cone margin status for risk of residual focal in patients with cervical adenocarcinoma in situ / 中国基层医药

ABSTRACT

Objective To observe the clinical value of the cervical conization operation margin in predicting residual focal in patients with adenocarcinoma in situ (ACIS).Methods 60 ACIS patients were reviewed,and postoperative specimens were analyzed.Negative resection margin was defined asno residual tumor epithelial cell was seen in operation margin around,and normal cervical epithelial cells can be visible.Relations between the margin status and incidence of residual were analyzed.Results The margin positive rate in LEEP was 56.8%,which was significantly higher than that in CKC(26.1 %,χ2 =5.390,P =0.02).The corrected odds was 4.31 (OD =4.31 , 95%CI 1 .1 3 -1 6.43,P =0.03).None had no residual tumor in 26 cases with margin negative,and 1 7 cases (65.4%)were detected with residual tumor in 26 positive margins (χ2 =25.257,P <0.01 ).Conclusion The ACIS patients with negative margins have a lower risk for residual focal.The standard sampling and judging methods in evaluating margin criteria can enhance the predictive value of margins.