Study on the correlation between MTHFR gene polymorphism and unexplained recurrent spontaneous abortion / 国际检验医学杂志
International Journal of Laboratory Medicine
;
(12): 16-17, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-509406
ABSTRACT
Objective To discuss the correlation between MTHFR gene polymorphism and unexplained recurrent spontaneous abortion.Methods A case control study was used in this study,140 patients with unexplained recurrent spontaneous abortion(UR-SA) (abortion group)and 143 cases of normal women(control group)were recruited.Genomic DNA was obtained and extracted from the oral mucosa cells.Fluorescence quantitative PCR was used to examine the MTHFR gene polymorphisms,and Taqman-MGB technology was conducted to analysis the relationship between single nucleotide polymorphism and disease.Results There was statistically significant difference in the frequencies of C677T genotype and alleles between the two groups(P<0.05).However,no significant difference in the frequencies of A1298C genotype and alleles between the two groups(P>0.05).Conclusion MTHFR gene C677T polymorphism might be one of the genetic risk factors of URSA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude observationnelle
/
Facteurs de risque
langue:
Chinois
Texte intégral:
International Journal of Laboratory Medicine
Année:
2017
Type:
Article
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