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In vitro Transdermal Absorption of Xiaochuan Ointment / 中国药师
China Pharmacist ; (12): 751-753, 2017.
Article Dans Chinois | WPRIM | ID: wpr-511646
ABSTRACT

Objective:

To study the transdermal absorption in vitro of sinapine thiocyanate,tetrahydropalmatine and asarinin in Xiaochuan ointment so as to offer reference for its clinical application.

Methods:

A Franz diffusion cells method with isolated rat skins was carried out to study the percutaneous rate of sinapine thiocyanate,tetrahydropalmatine and asarinin determined by LC-MS/MS.

Results:

With the increase of administration dosage,the cumulative penetration of sinapine thiocyanate,tetrahydropalmatine and asarinin showed few changes.The results showed that the transdermal behavior of sinapine thiocyanate fit to a Higuchi equation,and that of tetrahydropalmatine and asarinin fit zero-order process.The penetration rate of tetrahydropalmatine and asarinin respectively was 0.362×10-1 and 0.330×10-2 μg·cm-2·h-1.

Conclusion:

Xiaochuan ointment exhibits transdermal penetration and absorption properties,which provides evidence for its transdermal administration.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: China Pharmacist Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: China Pharmacist Année: 2017 Type: Article