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High Dose Intravitreal Bevacizumab for Refractory Pigment Epithelial Detachment in Age-related Macular Degeneration
Korean Journal of Ophthalmology ; : 265-271, 2016.
Article Dans Anglais | WPRIM | ID: wpr-51224
ABSTRACT

PURPOSE:

Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is the first choice of treatment for age-related macular degeneration. However, quite a few eyes treated using conventional dose anti-VEGF (CDAV) have persistent pigment epithelial detachment (PED) on optical coherence tomography. This study investigated the efficacy and safety of high dose anti-VEGF (HDAV) for refractory PED.

METHODS:

In this retrospective study, 31 eyes of neovascular age-related macular degeneration patients with persistent PED findings despite six or more intravitreal injections of CDAV (bevacizumab 1.25 mg or ranibizumab 2.5 mg) were analyzed. Changes in visual outcome, central foveal thickness, and PED height were compared before and after HDAV (bevacizumab 5.0 mg) for these refractory PED cases.

RESULTS:

The mean age of patients was 67.7 years. The number of CDAV injections was 12.1. The number of HDAV injections was 3.39. Best-corrected visual acuity in logarithm of the minimum angle of resolution before and after HDAV was 0.49 and 0.41 (p < 0.001), respectively. Central foveal thickness before and after HDAV was 330.06 and 311.10 µm (p = 0.125), respectively. PED height before and after HDAV was 230.28 and 204.07 µm (p = 0.014), respectively. There were no serious adverse reactions in all the eyes.

CONCLUSIONS:

Increasing the dose of bevacizumab in refractory PED may be a possible treatment option.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Décollement de la rétine / Angiographie fluorescéinique / Études rétrospectives / Inhibiteurs de l&apos;angiogenèse / Facteur de croissance endothéliale vasculaire de type A / Tomographie par cohérence optique / Relation dose-effet des médicaments / Épithélium pigmentaire de la rétine / Injections intravitréennes / Bévacizumab Type d'étude: Étude observationnelle Limites du sujet: Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Korean Journal of Ophthalmology Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Décollement de la rétine / Angiographie fluorescéinique / Études rétrospectives / Inhibiteurs de l&apos;angiogenèse / Facteur de croissance endothéliale vasculaire de type A / Tomographie par cohérence optique / Relation dose-effet des médicaments / Épithélium pigmentaire de la rétine / Injections intravitréennes / Bévacizumab Type d'étude: Étude observationnelle Limites du sujet: Adulte très âgé / Femelle / Humains / Mâle langue: Anglais Texte intégral: Korean Journal of Ophthalmology Année: 2016 Type: Article