PD-L1 and PD-L2 expressions in human breast cancer and their significance / 临床与实验病理学杂志

ABSTRACT

Purpose To investigate the expressions of costimulation molecules PD-L1 and PD-L2 in human breast cancers and their association with clinical and pathologic characteristics of the patients.Methods The expressions of PD-L1,PD-L2 in 10 cases of normal human breast tissue,18 cases of ductal carcinoma in situ,and 40 cases of breast cancer were detected by immunohistochemistry SP two-step staining,and the relationship between their expressions and clinical and pathologic characteristics was evaluated.Results There was no PD-L1 or PD-L2 expression in normal breast tissue,faint expressions of PD-L1 and PD-L2 were determined in ductal carcinoma in situ.45％ (18/40) PD-L1 and 35％ (14/40) PD-L2 were detected in breast cancers.PD-L1 and PD-L2 expression in cancer cells were related to the lymph node metastasis,ER and PR (P ＜ 0.05).High expression of PD-L1 and PD-L2 in breast cancer patients were correlated with negative ER,PR and HER-2 (P ＜ 0.05).Conclusion PD-L1 and PD-L2 express aberrantly in breast cancer and are closely associated with the lymph node metastasis of breast cancer.PD-L1 and PD-L2 may be the potential immunotherapy targets of breast cancer.