The effect of histamine H_2 receptor blocker famotidine on the gastric function and ulcer-index in rats of hemorrhagic stress / 中国病理生理杂志

ABSTRACT

The effect of a histamine H_2 receptor blocker-famotidine on the changes of blood volume and oxygen saturation in the gastric mucosa of rats under hemorragic stress was studied with reflectance spectrophotometry. The effects of famotidine on the volume of gastric juice and gastric acid excreted and also stress uIceration were studied at the same time. Before hemorrhage, famotidine (3mg. kg~(-1), 8mg.kg~(-1iv)) did not alter the blood volume and oxygen saturation in the gastric mucosa. Under hemorrhagic state, famotidine could prevent the decrease of blood volume and oxygen saturation in the gastric mucosa and decreased the volume of gastric juice and gastric acid secretions, and could also protect the rats from formation of stress ulcer.