Experimental Studies of Inducing Malignant Lung Tumor on Wistar Rats by Artificial Synthetic Tin Mine Dust / 昆明医科大学学报

ABSTRACT

There is a high incidence of malignant lung tumor in Yunnan tin mine area.In order to detect the causes,the mixtures of artificial synthetic mine dust containing As,Pb,Fe etc(No. 1,2,3)were used for tumor-inducing experiments on Wistar rats.The results were as follows 31 lung sarcomas were developed in 3 experimental groups and the incidence was 22.6%.The malignant lung lymphomas developed in 28 of 31 sarcomas,the rate being 90.2%.In addition, 3 cases of lung cancer were found.No benign or malignant lung tumor was found in the con- trol group.The results showed that the artificial synthetic mine dust(No.1,2,3)was related to the lung sarcoma formation on Wistar rats,which is reported for the first time.