Changes of ventricular relaxation, contractility and compliance and their effects on cardiac pump function during the development of chronic high output heart failure / 中国病理生理杂志

ABSTRACT

Changes of ventricular relaxation, contractility and compliance and their effects on cardiac pump function during the development of chronic high output heart failure were studied in the animal model produced by establishment of combined aorto-caval fistula (ACF) and unilateral renal artery stenosis (RAS) in rats.In the present study, all the rats with ACF+RAS showed the characteristics of high output hear failure of varying degree, the cardiac index rised significantly even at rest, while pump function reserving force (CORF) decreased to different extent.The resu(?)lts show that with the aggravation of cardiac pump function deterioration, ventricular relaxation and contractility decreased progressively, the ventricular diastolic compliance rised significantly. With stepwise regression analysis, the changes of ventricular relaxation, comtractility and compliance have different effects on cardiac pump function at different stage of heart failure.