The changes of PGI_2 and TXA_2 in the hepatic ischemic damage in rats and the protective role of indomethacin / 中国病理生理杂志

ABSTRACT

It is still contradictory whether PGI_2 and TXA_2 can influence hepatic is-chemic damage. Rats were divided into three groups at random. Group 1 and 2 were givensaline; group 3 were pretreated with indomethacin. 30 min before the induction of liverischemia drugs were injected into peritoneal cavity. After 2 h of ischemia and 2 hof reperfusion, the results showed that the TXB_2 content of ischemia group was higherand the P/T ratio was lower than that of the indomethacin group. The control groupshowed no change. Massive necrosis was observed in the ischemia group, but only focalnecrosis was seen in the indomethacin group. There was no hepatic necrosis in the controlgroup. The results suggested 1. TXA_2 was an important cell injury agent; 2. Indomethacinhave protective effect on the reperfusion liver cell injury.