Influence of ?-hydroxybutyric sodium on the pharmacokinetics of ketamine infusion in preschool children / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1996.
Article
Dans Chinois
| WPRIM
| ID: wpr-516750
ABSTRACT
Objective:
To determine the influence of ?-hydroxybutyric sodium (7-OH)on the pharmacokinetics of ketamine infusion in preschool children.Method:
Sixteen patients were randomly assigned to group Ⅱ (Ketamine) and group Ⅱ (Ketamine plus ?-OH). After trachea intubation,0.05% ketamine was infused in both groups at 3mg?kg~(-1)?h~(-1) and ?-OH 125mg?kg~(-1) only in group Ⅱ. The plasma concentration of ketamine was measured using high performance liquid chromatography. Pharmacokinetic parameters were calculated using 3P_(87) software composed by Chinese Pharmacologic Society.Result:
In both groups,pharmaeokinetics could be descrided as two-compartment open model. The T_(1/2)? and the Cl differ between group Ⅰ and group Ⅱ (P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Anesthesiology
Année:
1996
Type:
Article
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