The relations among PAMP, ADM and Ang Ⅱ on vascular tissue / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)1986.
Article
Dans Chinois
| WPRIM
| ID: wpr-516974
ABSTRACT
AIM:
To elucidate the relations among proadrenomedullin N terminal 20 peptide (PAMP), adrenomedullin(ADM) and angiotensin Ⅱ (Ang Ⅱ).METHODS:
Tissue slices of rat aorta were incubated as follows (I) increasing concentrations of Ang Ⅱ (10-9, 10-8, 10-) mol/L); (Ⅱ) increasing concentrations of PAMP(10-9, 10-8, 10-)mol/L). The tissue and incubation concentrations of PAMP, ADM and Ang Ⅱ were measured by the radioimmunoassay (RIA).RESULTS:
The tissue and incubation concentrations of PAMP and ADM were concentration - dependently increased by Ang Ⅱ, but the tissue and incubation concentrations of Ang Ⅱ can not effected by PAMP.CONCLUSION:
AngⅡ markedly stimulate the release of ADM and PAMP. It may be one of the factors which regu- late the synthesis and release of ADM and PAMP. The regulation may play an important role in homastasis regulation of cardiovascular system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pathophysiology
Année:
1986
Type:
Article
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