Effect of lidocaine on voltage-dependent sodium current in dissociated hippocampal neurons of the rat / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1995.
Article
Dans Chinois
| WPRIM
| ID: wpr-517168
ABSTRACT
Objective To study the effect of variant concentrations of lidocaine on voltage-dependent sodium current in dissociated hippocampal neurons of the ratMethods Voltage-dependent sodium currents in dissociated hippocampal neurons of the rat were recorded by whole-cell configuration of the patch clamp when a series of doses of lidocaine (10 -5mol/L-10 -2mol/L) were appliedResults Lidocaine reduced the amplitude of sodium current in a dose-dependent manner, with EC50 of (039?005)mmol/LConclusions Voltage-dependent sodium channel is related to cerebral protective effect of lidocaine, but has nothing to do with its nervous toxicity
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Anesthesiology
Année:
1995
Type:
Article
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