The Assessment of Proliferating Cell Nuclear Antigen (PCNA) in Cervical Tumors / 대한부인종양콜포스코피학회잡지
Korean Journal of Gynecologic Oncology and Colposcopy
;
: 1-9, 1994.
Article
Dans Coréen
| WPRIM
| ID: wpr-51879
ABSTRACT
Proliferating cell nuclear ntigen (FCNA) iis a nuclear protein that is syntheaimd in late Gl and S phases of cell cycle and is correlated with the cell proliferative stale. The recent study demonstrated that FCNA functions in 13NA replication. The present study evaluated proliferetive iindices (PI) for the assessment of tumor proliferation and for investigating prognostic significancx, in cervical tumors. lmmunohiatoehemical PCNA staining was perfurmed in formalin-fixed paraffin-embedded cervical tissues via the avidin-biotin-complex immunoperoxidase methad. Mean PI was 36.03+/-5.14% in normaI controls, as compared to 66.19+/-11.36% in cerviml intraepithelial neoplasia. and 63.19+/-10.94% in invasive cervical cancer. Our results showed no significant correlation between Pll and histological type. Among invasive cervical cancer (24 cases), PI waa 64.43+/-10.94% in squamoua cell carcinoma and 59.00+/-4.10% in adenocarcinoma. There was no eipiifiant relationship between Fl and clinical etage, and between PI and lesion size. This study auggeste that Pl may not serve as a new prognostie factor in cervical tumors.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéines nucléaires
/
Adénocarcinome
/
Cycle cellulaire
/
Tumeurs du col de l'utérus
/
Phase S
/
Antigène nucléaire de prolifération cellulaire
Type d'étude:
Étude pronostique
langue:
Coréen
Texte intégral:
Korean Journal of Gynecologic Oncology and Colposcopy
Année:
1994
Type:
Article
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