Effect of malnutrition on rocuronium induced neuromuscular blockade / 中华麻醉学杂志

ABSTRACT

Objective It has been reported that nutritional status of the patients affects neuromuscular (N-M) blockade induced by succinylcholine, tubocurarine, atracurium and vecuronium. The purpose of this study was to investigate the effect of malnutrition on rocuronium induced N-M block. Methods Forty ASA Ⅰ -Ⅱ patients undergoing surgery under general anesthesia were divided into four groups of 12 patients each, based on body mass index (BMI): I normal group BMI = 18.5-25kg? m-2 ;Ⅱ mild malnutrition group BMI= 17-18.5 kg?m-2 ;Ⅲ moderate malnutrition groups BMI = 16-17 kg?m-2 and Ⅳ severe malnutrition group BMK90% the patient was intubated and mechanically ventilated. PETCO2 was maintained at 4.0-4.7kPa. Anesthesia was maintained with 0.5%-0.7% isoflurane +60% N2O. During operation when T1 returned to 25% of control rocuronium 0.15mg?kg-1 was supplemented. The onset time, degree of N-M block and duration of action of initial and supplemental dose were recorded.Results With initial dose the onset time was delayed in group Ⅲ [(184?58)s] and group Ⅳ [(252?62) s] as compared with that in group Ⅰ [(122?33 )s] (P0.05) .Conclusions The neuromuscular blockade induced by rocuronium is reduced in patients with moderate and severe malnutrition.