Mitochondrial Control of Innate Immunity and Inflammation
Immune Network
;
: 77-88, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-51913
ABSTRACT
Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform regulating innate immune and inflammatory responses. Several mitochondrial proteins and mitochondrial reactive oxygen species have emerged as central players orchestrating the innate immune responses to pathogens and damaging ligands. This review explores our current understanding of the roles played by mitochondria in regulation of innate immunity and inflammatory responses. Recent advances in our understanding of the relationship between autophagy, mitochondria, and inflammasome activation are also briefly discussed. A comprehensive understanding of mitochondrial role in toll-like receptor-mediated innate immune responses and NLRP3 inflammasome complex activation, will facilitate development of novel therapeutics to treat various infectious, inflammatory, and autoimmune disorders.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Autophagie
/
Organites
/
Espèces réactives de l'oxygène
/
Protéines mitochondriales
/
Inflammasomes
/
Immunité innée
/
Inflammation
/
Ligands
/
Mitochondries
langue:
Anglais
Texte intégral:
Immune Network
Année:
2017
Type:
Article
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