Research on the Expression of Cyclin E and P27~(kip1) in Bladder Transitional Cell Carcinoma and its Relation With the Expression of Ki-67 / 中国医师杂志

ABSTRACT

Objective To investigate the expression of cell cycle regulating protein cyclin E and p27 kip1 in bladder transitional cell carcinoma (BTCC) and to evaluate its relation with the expression of Ki-67.Methods With immunohistochemistry assay , the expressions of cyclin E , p27 kip1 and Ki-67 were examined in 65 cases of BTCC and 12 cases of normal bladder tissue as controls.Results There was a positive correlation between cyclin E expression and the pathological grade(P