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Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes
Biomolecules & Therapeutics ; : 312-319, 2016.
Article Dans Anglais | WPRIM | ID: wpr-51941
ABSTRACT
Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to prevent apoptosis due to oxidative stress generated through UVB-induced ROS. Hesperidin significantly scavenged ROS generated by UVB radiation, attenuated the oxidation of cellular macromolecules, established mitochondrial membrane polarization, and prevented the release of cytochrome c into the cytosol. Hesperidin downregulated expression of caspase-9, caspase-3, and Bcl-2-associated X protein, and upregulated expression of B-cell lymphoma 2. Hesperidin absorbed wavelengths of light within the UVB range. In summary, hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis via its antioxidant and UVB absorption properties.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Peau / Kératinocytes / Lymphome B / Espèces réactives de l'oxygène / Apoptose / Stress oxydatif / Cytosol / Cytochromes c / Absorption / Membranes mitochondriales Limites du sujet: Humains langue: Anglais Texte intégral: Biomolecules & Therapeutics Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Peau / Kératinocytes / Lymphome B / Espèces réactives de l'oxygène / Apoptose / Stress oxydatif / Cytosol / Cytochromes c / Absorption / Membranes mitochondriales Limites du sujet: Humains langue: Anglais Texte intégral: Biomolecules & Therapeutics Année: 2016 Type: Article