Effects of propylthiouracil on body temperature in rats during cold exposure / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12)2000.
Article
Dans Chinois
| WPRIM
| ID: wpr-519841
ABSTRACT
AIM:
To investigate the effect of cold exposure on the thermoregulatory function in hypothyroid rats.METHODS:
Hypothyroid model was established by administration of antithyroid drug propylthiouracil(PTU) in rats. Colonic temperature was measured using digital thermometer. Plasma T_3 and T_4 concentrations were determined by radioimmunoassay. The effect of cold exposure on body temperature was observed after 2 weeks of PTU treatment.RESULTS:
Plasma T_3 and T_4 concentrations were reduced markedly 2 weeks after PTU treatment, and colonic temperature was also decreased markedly; Hyperthermic response was not different between PTU group and control group during cold exposure.CONCLUSION:
This study suggests that PTU-induced hypothyroid rat possesses a robust thermogenic response to short bouts of cold exposure.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pathophysiology
Année:
2000
Type:
Article
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