Rapid effects of dexamethasone on activation of ERK and p38 in HO-8910 cells / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)2000.
Article
de Zh
| WPRIM
| ID: wpr-519965
Bibliothèque responsable:
WPRO
ABSTRACT
AIM: To investigate the effects of synthetical glucocorticoid dexamethasone(Dex) on the activation of two members of mitogen-activated protein kinase (MAPK) family, extracellular signal-regulated protein kinase1/2(ERK1/2 ) and p38 MAPK (p38) in human ovarian cancer cell line HO-8910. METHODS: The activation of ERK1/2 and p38 was determined by Western blot. RESULTS: Inhibition of activation of ERK1 and ERK2 by 10 -7 mol/L Dex occurred at 5 min, with maximum up to 41% and 54% respectively at 30 min ( P
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Pathophysiology
Année:
2000
Type:
Article