Improvement of the Formulation of Clarithromycin Dispersible Tablets / 中国药房

ABSTRACT

OBJECTIVE:To obtain an optimum formulation of clarithromycin dispersible tablets METHODS:The preparation process was set by way of screening formulation and a formula with substitution of LS-HPC for starch was adopted RESULTS:The results showed that the substitution of LS-HPC for starch was the most preferable formulation The hardness and the friability of the tablets were improved The external apperance of unfilled corner and torn edge of the unimproved tablets was resolved CONCLUSION:Modified formulation is favorable for improving the quality of the product