Role of synovium macrophage during adjuvant arthritis in rat articular damage / 中国病理生理杂志

ABSTRACT

AIM: To explore the role of synovium macrophage of adjuvant arthritis (AA) rats in articular damage. METHODS: AA was induced in female Wistar rats by means of intradermal injection with complete Freud's adjuvant. X-ray on hind paws of AA rats was took at different time points and radiograph index (RI) was then evaluated. Synovium macrophages were detected through immunohistochemistry with ED 1 monoclonal antibody. The correlations between RI and synovial lining layer count/synovium macrophage count were also analysed. RESULTS: Synovial lining layer count, both macrophage count in synovial lining layer and sublining layer were positively correlated with RI. CONCLUSION: Synovium macrophages of AA rats may play an important role in articular damage.