Role of vascular endothelial growth factor and its receptor KDR in the progression of colorectal carcinoma / 中国普通外科杂志

ABSTRACT

Objective To investigate vascular endothelial growth factor (VEGF),its receptor KDR and angiogenesis in relation to progression of colorectal carcinoma (CC). Methods KDR,VEGF protein expression and microvessel density (MVD) in 102 cases of human CC were examined by immunohistochemical staining. MVD,KDR and VEGF expression were analysed with their relation to histological grade,depth of invasion,Dukes stage,lymph node metastasis,liver metastasis and prognosis of CC. Results MVD was significantly higher in KDR and VEGF-positive CC than in KDR and VEGF-negative CC ( P