Polymorphism of Haptoglobin in Patients with Premature Rupture of Membrane
Yonsei Medical Journal
;
: 132-136, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-52282
ABSTRACT
PURPOSE:
To investigate whether allelic polymorphism of haptoglobin (Hp) is associated with premature rupture of membrane (PROM), the Hp phenotypes of pregnant women with PROM were analyzed. PATIENTS ANDMETHODS:
The Hp phenotypes of 221 pregnant Korean women (187 control and 34 PROM patients) were determined by benzidine/hydrogen peroxide staining, following native polyacrylamide gel electrophoresis of hemoglobin-mixed sera. The Hp allele frequencies were calculated from the data of Hp phenotypes, and overall association with PROM was evaluated using Pearson Chi-Square test.RESULTS:
The polymorphic distribution of the patients cohort who underwent a normal delivery (control group) was similar to that of healthy Koreans. In contrast, however, patients with PROM showed significantly higher occurrence of the Hp 1-1 phenotype than control group (23.5% vs 8.0%). Hp 2-2 phenotype was lower in PROM cohort (38.2%) than in the control group (48.7%). The Hp1 allele frequency in PROM group was significantly higher than that in the control group (0.426 vs 0.297, p = 0.034) with odds ratio of 1.762 (95% CI 1.038 - 2.991).CONCLUSION:
These findings suggest that pregnant Korean women who possess Hp1 allele (expressed as Hp 1-1 phenotype) have higher incidence of PROM than women with Hp2 allele (expressed as Hp 2-2 phenotype). This is the first study that evaluated the significance of Hp polymorphism with respect to the development of PROM.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénotype
/
Polymorphisme génétique
/
Rupture prématurée des membranes foetales
/
Haptoglobines
/
Incidence
/
Prédisposition génétique à une maladie
/
Asiatiques
/
Fréquence d'allèle
/
Corée
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2009
Type:
Article
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