Effects of Bone-tonifying Capsule on Bone Morphology and Serum TNF-?of the Osteoporosis Model Rats / 中国药房

ABSTRACT

OBJECTIVE:To study the effects of bone-tonifying capsule on bone morphology and serum TNF-?level of the osteoporosis(OP)model rats.METHODS:The rats were divided into sham operation group,model group and treatment group.OP model were established by removing ovaries of both sides in both the model group and the treatment group by o-variectomy,then the bone density of each group was determined;the bone morphology was observed in the decalcified section of bone tissue;the concentration of serum estradiol(E 2 )and TNF-?level were determined by radioimimunoassay.RESULTS:Compared with the sham group,the bone density and serum E 2 level lowed yet the TNF-?level increased in the model group(P