Clinicopathologic and prognostic significance of thymidine phosphorylase and dihydropyrimidine dehydrogenase activity in human colorectal carcinoma / 中国普通外科杂志
Chinese Journal of General Surgery
;
(12)2001.
Article
Dans Chinois
| WPRIM
| ID: wpr-525267
ABSTRACT
Objective This study was to investigate the relationship between the activities of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) and clinicopathological parameters in human colorectal cancer,and the relationship between TP and/or DPD activity in tumor tissue and efficiency of chemotherapy. MethodsSixty-eight patients undergoing surgery for primary colorectal cancer were enrolled including 40 patients receiving postoperative adjuvant chemotherapy with 5-FU plus leucovorin(de Gramont regimen). The activities of TP and DPD both in tumor tissue and in normal tissue were determined by enzyme-linked immunosorbent assay(ELISA). Results The TP activity was significantly higher in tumor than in normal tissues(P
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Étude pronostique
langue:
Chinois
Texte intégral:
Chinese Journal of General Surgery
Année:
2001
Type:
Article
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