Preparation and Quality Control of Ornidazole-?-Cyclodextrin Inclusion Compound / 中国药房

ABSTRACT

OBJECTIVE:To prepare ornidazole-?-cyclodextrin inclusion compound and establish its quality control method.METHODS:The ornidazole-?-cyclodextrin inclusion compound was prepared by saturated water solution method and the content was determined by ultraviolet spectrophotometry.RESULTS:The finished preparation was confirmed to be ornidazole-?-cyclodextrin inclusion compound under the microscope.The detection concentration range of ornidazole was5.1～20.5?g/ml(r=0.9999);the average recovery rate was101.52%,RSD=1.4%.CONCLUSION:This preparation method is practicable;the finished preparation is stable in quality and the established quality control method is simple,reliable.