Implication of aspirin resistance: Simple laboratory finding or important clinical criteria? / 대한내과학회지
Korean Journal of Medicine
;
: 682-684, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-52663
ABSTRACT
Aspirin resistance defined by light transmittance aggregometry (LTA) or urinary 11-dehydro-thromboxane B2 has been associated with an increased risk of adverse clinical events. However, aspirin resistance based on the point-of-care VerifyNow-Aspirin assay (aspirin reaction unit > or = 550) shows poor sensitivity compared with LTA. In aspirin-treated patients, activation by cyclooxygenase- independent pathways may be associated with residual platelet reactivity, which may cause adverse clinical outcomes in some portion. A large-scale, prospective study using several platelet function assays should be performed to establish the long-term clinical significance of antiplatelet resistance in Korean patients treated with coronary stenting. Accordingly, we can apply tailored antiplatelet therapy in resistant patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Thromboxane B2
/
Plaquettes
/
Endoprothèses
/
Acide acétylsalicylique
/
Études prospectives
/
Lumière
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
2009
Type:
Article
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